Frequent loss of the short arm of chromosome 9 in resected non-small-cell lung cancers from Japanese patients and its association with squamous cell carcinoma

@article{Kishimoto1995FrequentLO,
  title={Frequent loss of the short arm of chromosome 9 in resected non-small-cell lung cancers from Japanese patients and its association with squamous cell carcinoma},
  author={Yosuke Kishimoto and Kenji Sugio and Tetsuya Mitsudomi and Tsunehiro Oyama and Arvind K. Virmani and Donald D. Mcintire and Adi F. Gazdar},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={1995},
  volume={121},
  pages={291-296}
}
We analyzed 87 Japanese non-small-cell lung carcinomas (NSCLC), including 30 squamous cell, 51 adenocarcinomas and 6 large-cell carcinomas for loss of heterozygosity (LOH) on the short arm of chromosome 9, and we correlated our findings with clinicopathological features. We used four polymorphic microsatellite markers on 9p (interferon A gene, D9S171, D9S126, and D9S169), which flank the critical region (9p21-22) involved in lung cancer. We observed alterations of DNA sequences at 9p in NSCLC… CONTINUE READING