• Biology, Medicine
  • Published in Molecular carcinogenesis 2001
  • DOI:10.1002/mc.1053

Frequent loss of imprinting of IGF2 and MEST in lung adenocarcinoma.

@article{Kohda2001FrequentLO,
  title={Frequent loss of imprinting of IGF2 and MEST in lung adenocarcinoma.},
  author={Masahiko Kohda and Hidetoshi Hoshiya and Motonobu Katoh and Ippei Tanaka and Reiji Masuda and Tomonari Takemura and Michihiro Fujiwara and Mitsuo Oshimura},
  journal={Molecular carcinogenesis},
  year={2001},
  volume={31 4},
  pages={
          184-91
        }
}
Genomic imprinting is a parental origin-specific chromosomal modification that causes differential expression of maternal and paternal alleles of a gene. Accumulating evidence suggests that deregulation of imprinted genes, including loss of imprinting (LOI), plays a role in oncogenesis. In the present study, we investigated allelic expression of six imprinted genes in human lung adenocarcinomas as well as in matched normal lung tissue. Informative cases showing heterozygosity for the gene of… CONTINUE READING

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