Frequent loss of SMAD4/DPC4 protein in colorectal cancers.

  title={Frequent loss of SMAD4/DPC4 protein in colorectal cancers.},
  author={Reijo Salovaara and Sabine Roth and Anu Loukola and Virpi Launonen and P Sistonen and Egle Avizienyte and Paula Kristo and Heikki J{\"a}rvinen and Serhiy Souchelnytskyi and Maarit Sarlomo-Rikala and Lauri A. Aaltonen},
  volume={51 1},
BACKGROUND AND AIMS Loss of DNA sequences from chromosome 18q21 is a major genetic change in colorectal tumorigenesis. Multiple genes have been identified in this area. One of these, DPC4 (deleted in pancreatic cancer 4, also known as SMAD4), is mutated in a minor subset of colorectal carcinomas as well as in germlines of humans predisposed to colon tumours. PATIENTS AND METHODS The involvement of SMAD4 in sporadic colorectal neoplasia was evaluated by immunohistochemistry in 53 unselected… CONTINUE READING
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Higher frequency of Smad 4 gene mutation in human colorectal cancer with distant metastasis

  • M Koyama, M Ito, H Nagai
  • Oncogene
  • 1999

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