Frequent loss of RUNX3 expression by promoter hypermethylation in gastric carcinoma.

@article{Oshimo2004FrequentLO,
  title={Frequent loss of RUNX3 expression by promoter hypermethylation in gastric carcinoma.},
  author={Yasuhiro Oshimo and Naohide Oue and Yoshitsugu Mitani and Hirofumi Nakayama and Yasuhiko Kitadai and Kazuhiro Yoshida and Yoshiaki Ito and Kazuaki Chayama and Wataru Yasui},
  journal={Pathobiology : journal of immunopathology, molecular and cellular biology},
  year={2004},
  volume={71 3},
  pages={137-43}
}
The RUNX3 gene is a member of the Runt domain family of transcription factors that are master regulators of gene expression in major developmental pathways. Recently, lack of RUNX3 function was found to be associated with genesis and progression of gastric carcinoma. We studied methylation of CpG islands in the RUNX3 gene by methylation-specific PCR in 80 gastric carcinoma specimens, 45 corresponding non-neoplastic mucosae, and 7 gastric carcinoma cell lines. We also measured levels of RUNX3… CONTINUE READING