Frequent integration of precore/core mutants of hepatitis B virus in human hepatocellular carcinoma tissues.

@article{Zhong2000FrequentIO,
  title={Frequent integration of precore/core mutants of hepatitis B virus in human hepatocellular carcinoma tissues.},
  author={Sheng Zhong and John Y. H. Chan and Winnie Yeo and John S. Tam and Phillip J. Johnson},
  journal={Journal of viral hepatitis},
  year={2000},
  volume={7 2},
  pages={115-23}
}
The development of hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC) frequently follows persistent HBV infection and may arise in individuals who are hepatitis B e antigen (HBeAg) negative, indicating the possible presence of precore/core mutants. It is unclear whether precore/core mutants are associated with tumour development or are selected for after chromosomal integration of the wild-type viral DNA. We studied the status and sequence variation of the precore/core region of… CONTINUE READING

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The nt 1896 mutant was found in 5.6% ( one of 18 ) of patients with acute hepatitis B and in 22.8% ( nine of 35 ) of patients with chronic hepatitis B. However , the nt 1898 mutation was not found in any of these sera .
The precore / core mutant was observed with increasing frequency from acute hepatitis to chronic hepatitis , non - tumour and HCC , and this difference in frequency was significant between HCC and acute hepatitis B groups ( P < 0.01 ) , suggesting that the precore / core mutant or hepatocytes harbouring this mutant may be under immune selection and that such mutations may facilitate integration and subsequent tumour development .
The precore / core mutant was observed with increasing frequency from acute hepatitis to chronic hepatitis , non - tumour and HCC , and this difference in frequency was significant between HCC and acute hepatitis B groups ( P < 0.01 ) , suggesting that the precore / core mutant or hepatocytes harbouring this mutant may be under immune selection and that such mutations may facilitate integration and subsequent tumour development .
The precore / core mutant was observed with increasing frequency from acute hepatitis to chronic hepatitis , non - tumour and HCC , and this difference in frequency was significant between HCC and acute hepatitis B groups ( P < 0.01 ) , suggesting that the precore / core mutant or hepatocytes harbouring this mutant may be under immune selection and that such mutations may facilitate integration and subsequent tumour development .
The nt 1896 mutant was found in 5.6% ( one of 18 ) of patients with acute hepatitis B and in 22.8% ( nine of 35 ) of patients with chronic hepatitis B. However , the nt 1898 mutation was not found in any of these sera .
The precore / core mutant was observed with increasing frequency from acute hepatitis to chronic hepatitis , non - tumour and HCC , and this difference in frequency was significant between HCC and acute hepatitis B groups ( P < 0.01 ) , suggesting that the precore / core mutant or hepatocytes harbouring this mutant may be under immune selection and that such mutations may facilitate integration and subsequent tumour development .
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