Frequent hypermethylation of the DNA repair gene MGMT in long-term survivors of glioblastoma multiforme

@article{Martnez2006FrequentHO,
  title={Frequent hypermethylation of the DNA repair gene MGMT in long-term survivors of glioblastoma multiforme},
  author={Ram{\'o}n Mart{\'i}nez and Gabriele Schackert and Ricardo Yaya-tur and I{\~n}igo Rojas-Marcos and James Gordon Herman and Manel Esteller},
  journal={Journal of Neuro-Oncology},
  year={2006},
  volume={83},
  pages={91-93}
}
We have performed a methylation-specific PCR approach to comparatively analyze the MGMT promoter methylation status in 186 glioblastomas (GBM) from patients with classic survival and nine from patients with long-term survival (LTS GBM). The methylation rate in LTS GBM was significantly higher (77.8% vs. 39.2%, P = 0.033) which suggests that MGMT hypermethylation is a frequent hallmark of LTS GBM and contributes to characterize this intriguing GBM subtype. 
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The genome of long-term survivors in glioblastoma is differentially methylated relative to short-term survivor patients depending on CpG density: hypermethylation near CpGs islands (CGIs) and hypomethylation far from CGIs and these two patterns are associated with distinct oncogenic aspects in gliomagenesis.
Transcriptional diversity of long-term glioblastoma survivors.
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While IDH mutant proneural tumors impart a better prognosis in the short-term, survival beyond 4 years does not require IDH mutation and is not dictated by a single transcriptional subclass, in contrast, MGMT methylation continues to have strong prognostic value for survival Beyond 4 years.
Polymorphisms of LIG4, BTBD2, HMGA2, and RTEL1 genes involved in the double-strand break repair pathway predict glioblastoma survival.
  • Yanhong Liu, S. Shete, M. Bondy
  • Medicine, Biology
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2010
TLDR
Polymorphisms in the LIG4, BTBD2, HMGA2, and RTEL1 genes, which are involved in the double-strand break repair pathway, are associated with GBM survival.
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