Frequent hepatocyte growth factor overexpression and low frequency of c-Met gene amplification in human papillomavirus-negative tonsillar squamous cell carcinoma and their prognostic significances.

@article{Kwon2014FrequentHG,
  title={Frequent hepatocyte growth factor overexpression and low frequency of c-Met gene amplification in human papillomavirus-negative tonsillar squamous cell carcinoma and their prognostic significances.},
  author={Mi Jung Kwon and Dong Hoon Kim and H R Park and Hyung Sik Shin and Ji Hyun Kwon and Dong Jin Lee and Jin Hwan Kim and Seong Jin Cho and Eun Sook Nam},
  journal={Human pathology},
  year={2014},
  volume={45 7},
  pages={1327-38}
}
Human papillomavirus (HPV) is an important prognostic factor for tonsillar squamous cell carcinoma (TSCC). HPV-positive and HPV-negative TSCCs are considered distinct in terms of prognosis and sensitivity to chemo/radiotherapy. However, to date, no study has thoroughly evaluated the individual prognostic factors for these 2 disease subgroups. Hepatocyte growth factor (HGF)-Met signaling pathway can be a predictive marker for prognosis or therapy response, especially in HPV-negative TSCC. We… CONTINUE READING

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