Frequent gain of the p40/p51/p63 gene locus in primary head and neck squamous cell carcinoma.

  title={Frequent gain of the p40/p51/p63 gene locus in primary head and neck squamous cell carcinoma.},
  author={Kohei Yamaguchi and Lanyan Wu and Otavia L. Caballero and Kenji Hibi and Barry Trink and Vicente A. Resto and Paul M. Cairns and Kenji Okami and Wayne M Koch and David Sidransky and Jin Jen},
  journal={International journal of cancer},
  volume={86 5},
We have identified a new human p53 homologue, p40 (p51/p63). This gene was mapped to the distal arm of 3q and was found to be essential for normal epithelial development. We used microsatellite and FISH analyses to search for genetic alterations of p40 in primary HNSCC. A more precise localization of p40 was completed using 6 known markers on 3q and a newly isolated microsatellite marker within the p40 gene. We also determined the genomic organization of the p40 gene using human YAC and BAC… CONTINUE READING
Highly Cited
This paper has 118 citations. REVIEW CITATIONS


Publications citing this paper.
Showing 1-10 of 55 extracted citations

Expression of p63 in Reactive Hyperplasias and Malignant Lymphomas

Journal of Korean medical science • 2005
View 8 Excerpts
Highly Influenced

118 Citations

Citations per Year
Semantic Scholar estimates that this publication has 118 citations based on the available data.

See our FAQ for additional information.