Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors.

@article{Koontz2001FrequentFO,
  title={Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors.},
  author={Jason Koontz and A L Soreng and Marisa R. Nucci and Frank C. Kuo and Patrick Pauwels and Herman Van den Berghe and Paola Dal Cin and Jonathan Alfred Fletcher and Jeffrey Sklar},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 11},
  pages={6348-53}
}
Endometrial stromal tumors are divided into three types: benign stromal nodules, endometrial stromal sarcomas, and undifferentiated endometrial sarcomas. A variety of cytogenetic abnormalities involving chromosome 7 have been reported in endometrial stromal sarcomas, including a recurrent t(7;17)(p15;q21). We have identified two zinc finger genes, which we have termed JAZF1 and JJAZ1, at the sites of the 7p15 and 17q21 breakpoints. Analyses of tumor RNA indicate that a JAZF1/JJAZ1 fusion is… CONTINUE READING