Frequent epigenetic inactivation of KIBRA, an upstream member of the Salvador/Warts/Hippo (SWH) tumor suppressor network, is associated with specific genetic event in B-cell acute lymphocytic leukemia.

@article{Hill2011FrequentEI,
  title={Frequent epigenetic inactivation of KIBRA, an upstream member of the Salvador/Warts/Hippo (SWH) tumor suppressor network, is associated with specific genetic event in B-cell acute lymphocytic leukemia.},
  author={Victoria K. Hill and Thomas L. Dunwell and Daniel R. Catchpoole and D. R. R. Krex and Anna Teresa Brini and Michael J Griffiths and Charles G. Craddock and Eamonn R Maher and Farida Latif},
  journal={Epigenetics},
  year={2011},
  volume={6 3},
  pages={
          326-32
        }
}
The WW-domain containing protein KIBRA has recently been identified as a new member of the Salvador/Warts/Hippo (SWH) pathway in Drosophila and is shown to act as a tumor suppressor gene in Drosophila. This pathway is conserved in humans and members of the pathway have been shown to act as tumor suppressor genes in mammalian systems. We determined the methylation status of the 5' CpG island associated with the KIBRA gene in human cancers. In a large panel of cancer cell lines representing… CONTINUE READING

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