Frequent deletions at 11q23 and 13q14 in B cell prolymphocytic leukemia (B-PLL)

@article{Lens2000FrequentDA,
  title={Frequent deletions at 11q23 and 13q14 in B cell prolymphocytic leukemia (B-PLL)},
  author={Dimitri Lens and Estella Matutes and Daniel Catovsky and L J A Coignet},
  journal={Leukemia},
  year={2000},
  volume={14},
  pages={427-430}
}
Deletions of the long arm of chromosomes 11 and 13 are the most frequent structural chromosome aberrations in various types of lymphoproliferative disorders. However, these regions have not been studied so far in B cell prolymphocytic leukemia (B-PLL). We have investigated the incidence of 13q deletions in 18 B-PLL cases by fluorescence in situ hybridization (FISH), using molecular probes for the RB1 and D13S25 loci. Chromosome 11q deletions were evaluated by FISH using the yeast artificial… CONTINUE READING
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