Frequent clonal proliferation of human T-cell leukemia virus type 1 (HTLV-1)-infected T cells in HTLV-1-associated myelopathy (HAM-TSP).

@article{Furukawa1992FrequentCP,
  title={Frequent clonal proliferation of human T-cell leukemia virus type 1 (HTLV-1)-infected T cells in HTLV-1-associated myelopathy (HAM-TSP).},
  author={Yoshitaka Furukawa and Jun-Ichi Fujisawa and Mitsuhiro Osame and Masami Toita and S Eiichiro Sonoda and Ryuji Kubota and Shinji Ijichi and Mitsuaki Yoshida},
  journal={Blood},
  year={1992},
  volume={80 4},
  pages={1012-6}
}
Human T-cell leukemia virus type 1 (HTLV-1) integrates its proviruses into random sites in host chromosomal DNA. Random integration of the proviruses was observed in asymptomatic HTLV-1 carriers and patients with HTLV-1-associated myelopathy (HAM/TSP). However, clonal integration has been reported in patients with adult T-cell leukemia (ATL), including that in the smoldering, chronic, and acute states, indicating clonal expansion of infected cells. In this study, we found that about 20% of HAM… CONTINUE READING