Frequent attenuation of the WWOX tumor suppressor in osteosarcoma is associated with increased tumorigenicity and aberrant RUNX2 expression.

@article{Kurek2010FrequentAO,
  title={Frequent attenuation of the WWOX tumor suppressor in osteosarcoma is associated with increased tumorigenicity and aberrant RUNX2 expression.},
  author={K. Kurek and Sara Del Mare and Z. Salah and S. Abdeen and Hussain Sadiq and Suk-hee Lee and E. Gaudio and N. Zanesi and K. Jones and B. Deyoung and G. Amir and M. Gebhardt and M. Warman and G. Stein and J. Stein and J. Lian and R. Aqeilan},
  journal={Cancer research},
  year={2010},
  volume={70 13},
  pages={
          5577-86
        }
}
  • K. Kurek, Sara Del Mare, +14 authors R. Aqeilan
  • Published 2010
  • Biology, Medicine
  • Cancer research
  • The WW domain-containing oxidoreductase (WWOX) is a tumor suppressor that is deleted or attenuated in most human tumors. Wwox-deficient mice develop osteosarcoma (OS), an aggressive bone tumor with poor prognosis that often metastasizes to lung. On the basis of these observations, we examined the status of WWOX in human OS specimens and cell lines. In human OS clinical samples, WWOX expression was absent or reduced in 58% of tumors examined (P < 0.0001). Compared with the primary tumors, WWOX… CONTINUE READING
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