Frequent and symmetric deposition of misfolded tau oligomers within presynaptic and postsynaptic terminals in Alzheimer’s disease

@inproceedings{Tai2014FrequentAS,
  title={Frequent and symmetric deposition of misfolded tau oligomers within presynaptic and postsynaptic terminals in Alzheimer’s disease},
  author={Hwan-Ching Tai and Bo Yong Wang and Alberto Serrano–Pozo and Matthew P. Frosch and Tara L Spires-Jones and Bradley T. Hyman},
  booktitle={Acta neuropathologica communications},
  year={2014}
}
The accumulation of neurofibrillary tangles in Alzheimer’s disease (AD) propagates with characteristic spatiotemporal patterns which follow brain network connections, implying trans-synaptic transmission of tauopathy. Since misfolded tau has been shown to transmit across synapses in AD animal models, we hypothesized that synapses in AD patients may contain misfolded tau. By immunofluorescence imaging of bipartite synapses from AD subjects, we detected tau protein in 38.4% of presynaptic and 50… CONTINUE READING

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