Frequent and extensive deletion during the 9,22 translocation in CML.

  title={Frequent and extensive deletion during the 9,22 translocation in CML.},
  author={D W Popenoe and K E Schaefer-Rego and John Gregory Mears and Allan Bank and David Leibowitz},
  volume={68 5},
Chromosomal translocation is one mechanism by which cellular oncogenes may be activated during tumorigenesis. The translocation of the abl oncogene to the Philadelphia chromosome in chronic myelogenous leukemia (CML) results in a new RNA transcript that fuses sequence from chromosome 22 to sequence from the abl oncogene. This RNA presumably codes for a new abl-related protein product found in CML, the activity of which is different from the normal abl protein. The molecular structure of the… CONTINUE READING


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Detection of cabl tyrosine kinase activity in vitro permits direct comparison of normal and altered abl gene products

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