Frequent and characteristic K-ras activation and absence of p53 protein accumulation in aberrant crypt foci of the colon.

@article{Yamashita1995FrequentAC,
  title={Frequent and characteristic K-ras activation and absence of p53 protein accumulation in aberrant crypt foci of the colon.},
  author={Naoyuki Yamashita and Toshinari Minamoto and Atsuhi Ochiai and Munehiko Onda and Hiroyasu Esumi},
  journal={Gastroenterology},
  year={1995},
  volume={108 2},
  pages={434-40}
}
BACKGROUND/AIMS The relationship of aberrant crypt foci (ACF) to colorectal carcinogenesis is still controversial. Histological examination and analyses of K-ras mutations and p53 gene expression were performed to characterize ACF. METHODS ACF were identified microscopically in grossly normal colorectal mucosa. The ACF were separated into two pieces, one for histological and immunohistochemical examinations and the other for molecular analysis. K-ras mutations in codons 12 and 13 were… CONTINUE READING

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