Frequent and Yet Unreported GNAQ and GNA11 Mutations are Found in Uveal Melanomas

Abstract

Malignant melanoma of the uvea is the most common primary malignant tumor in the eye. We aimed to analyze GNAQ and GNA11 mutations in uveal melanomas using formalin-fixed, paraffin-embedded material and correlate the results with clinicopathological parameters. Tumor tissue was microdissected followed by amplification of GNAQ exon 4 and 5, GNA11 exon 4 and… (More)
DOI: 10.1007/s12253-017-0371-7

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@article{Schneider2017FrequentAY, title={Frequent and Yet Unreported GNAQ and GNA11 Mutations are Found in Uveal Melanomas}, author={Bjoern Schneider and Katrin Riedel and Andrey Zhivov and Maja Huehns and Heike Zettl and Rudolf F. Guthoff and Anselm G. M. Juenemann and Andreas Erbersdobler and Annette Zimpfer}, journal={Pathology & Oncology Research}, year={2017}, pages={1-7} }