Frequent amplifications and abundant expression of TRIO, NKD2, and IRX2 in soft tissue sarcomas.

@article{Adamowicz2006FrequentAA,
  title={Frequent amplifications and abundant expression of TRIO, NKD2, and IRX2 in soft tissue sarcomas.},
  author={Martyna Adamowicz and Bernhard Radlwimmer and Ralf J. Rieker and Daniel Mertens and Matthias Heinrich Martin Schwarzbach and Peter Schraml and Axel Benner and Peter Lichter and Gunhild Mechtersheimer and Stefan Joos},
  journal={Genes, chromosomes & cancer},
  year={2006},
  volume={45 9},
  pages={829-38}
}
Copy number gains and high-level amplifications of the short arm of chromosome 5 are frequently observed in soft tissue sarcomas. To identify genes from this region possibly involved in tumor progression, we analyzed 34 soft tissue sarcomas (10 pleomorphic and 8 dedifferentiated liposarcomas, 6 malignant fibrous histiocytomas, and 10 malignant peripheral nerve sheath tumors (MPNST)) using a DNA microarray including 418 BAC clones representing 99% of chromosome arm 5p. In seven tumors, distinct… CONTINUE READING

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