Frequent amplification of the c-met gene in scirrhous type stomach cancer.

  title={Frequent amplification of the c-met gene in scirrhous type stomach cancer.},
  author={Hiroki Kuniyasu and Wataru Yasui and Yasuhiko Kitadai and Hiroshi Yokozaki and Hisao Ito and Eiichi Tahara},
  journal={Biochemical and biophysical research communications},
  volume={189 1},
Amplification of the c-met gene, that encodes hepatocyte growth factor receptor, was examined on human esophageal, gastric and colorectal carcinomas. Six (55%) of the 11 gastric carcinoma cell lines and 15 (23%) of the 64 advanced gastric carcinomas showed the c-met gene amplification. Among them, c-met amplification was detected in 5 gastric cancer cell lines, derived from scirrhous gastric carcinoma and in 5 (38%) of 13 scirrhous gastric carcinoma tissues. Furthermore, patients of gastric… CONTINUE READING
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