Frequent alterations of SLIT2–ROBO1–CDC42 signalling pathway in breast cancer: clinicopathological correlation

@article{Bhattacharya2016FrequentAO,
  title={Frequent alterations of SLIT2–ROBO1–CDC42 signalling pathway in breast cancer: clinicopathological correlation},
  author={Rittwika Bhattacharya and Nupur Mukherjee and Hemantika Dasgupta and Md. Saimul Islam and N. Y. Intekhab Alam and Anup Roy and Priyobrata Das and Susanta Roychoudhury and Chinmay Kumar Panda},
  journal={Journal of Genetics},
  year={2016},
  volume={95},
  pages={551-563}
}
The aim of the study was to understand the role of SLIT2–ROBO1/2–CDC42 signalling pathways in development of breast cancer (BC). Primary BC samples (n=150), comprising of almost equal proportion of four subtypes were tested for molecular alterations of SLIT2, ROBO1, ROBO2 and CDC42, the key regulator genes of this pathway. Deletion and methylation frequencies of the candidate genes were seen in the following order: deletion, SLIT2 (38.6%) >ROBO1 (30%) >ROBO2 (7.3%); methylation, SLIT2 (63.3… CONTINUE READING
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