Frequent alterations in the Wnt signaling pathway in colorectal cancer with microsatellite instability.

@article{Shimizu2002FrequentAI,
  title={Frequent alterations in the Wnt signaling pathway in colorectal cancer with microsatellite instability.},
  author={Yosuke Shimizu and Satoshi Ikeda and Masahiko Fujimori and Shinya Kodama and Masahiro Nakahara and Masazumi Okajima and Toshimasa Asahara},
  journal={Genes, chromosomes & cancer},
  year={2002},
  volume={33 1},
  pages={73-81}
}
It is generally accepted that both dysfunction of the Wnt signaling pathway, including mutations in the adenomatous polyposis coli (APC) and beta-catenin genes, and genetic instability play important roles in colorectal carcinogenesis. However, alteration of the components in the Wnt signaling pathway in colorectal cancer (CRC) with microsatellite instability (MSI) has not been elucidated. In order to assess the status of the Wnt signaling components in CRC with MSI, mutational analyses of the… CONTINUE READING
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