Frequent alteration of p16(INK4a)/p14(ARF) and p53 pathways in the round cell component of myxoid/round cell liposarcoma: p53 gene alterations and reduced p14(ARF) expression both correlate with poor prognosis.

@article{Oda2005FrequentAO,
  title={Frequent alteration of p16(INK4a)/p14(ARF) and p53 pathways in the round cell component of myxoid/round cell liposarcoma: p53 gene alterations and reduced p14(ARF) expression both correlate with poor prognosis.},
  author={Yoshinao Oda and Hidetaka Yamamoto and Tomonari Takahira and Chikashi Kobayashi and Kenichi Kawaguchi and Naomi Tateishi and Yoko Nozuka and Sadafumi Tamiya and Kazuhiro Tanaka and Shuichi Matsuda and Ryohei Yokoyama and Yukihide Iwamoto and Masazumi Tsuneyoshi},
  journal={The Journal of pathology},
  year={2005},
  volume={207 4},
  pages={410-21}
}
In myxoid/round cell liposarcoma (MLS/RCLS), the presence of a round cell (RC) component has been reported to correlate with a worse prognosis for the patients. However, little is known about the molecular genetic differences between conventional myxoid (MX) components and RC components in this tumour. The aim of this study was to investigate the possible implications of molecular alterations of G1 to S-phase check-point genes, especially in the RC component. We evaluated the… CONTINUE READING

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