Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas.

  title={Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas.},
  author={Xiaoli Ma and Kai Chen and Shuhong Huang and Xiaoli Zhang and Patrick A. Adegboyega and Bernard Mark Evers and Hongwei Zhang and Jingwu Xie},
  volume={26 10},
The hedgehog pathway plays a critical role in the development of the foregut. Recent studies indicate that the hedgehog pathway activation occurs in the stomach and other gastrointestinal cancers. However, the association of hedgehog pathway activation with tumor stage, differentiation and tumor subtype is not well documented. Here, we report our findings that the elevated expression of hedgehog target genes human patched gene 1 (PTCH1) or Gli1 occurs in 63 of the 99 primary gastric cancers… CONTINUE READING


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