Frequent activation of AKT2 kinase in human pancreatic carcinomas.

  title={Frequent activation of AKT2 kinase in human pancreatic carcinomas.},
  author={Deborah A Altomare and Satoshi Tanno and Assunta De Rienzo and Andres J. P. Klein-Szanto and Sachie Tanno and Kristine L. Skele and John Parker Hoffman and Joseph R Testa},
  journal={Journal of cellular biochemistry},
  volume={87 4},
Activation of AKT/protein kinase B promotes a variety of biological activities important in tumorigenesis, such as cell survival and cell cycle progression. We previously demonstrated amplification and overexpression of the AKT2 gene in a subset of human pancreatic carcinomas. In this investigation, we assessed AKT2 catalytic activity in 50 frozen pancreatic tissues (37 carcinomas, four benign tumors and nine normal pancreata) by in vitro kinase assay. Twelve of 37 (32%) pancreatic carcinomas… CONTINUE READING
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