Frequent Somatic Mutation in Adult Intestinal Stem Cells Drives Neoplasia and Genetic Mosaicism during Aging

@inproceedings{Siudeja2015FrequentSM,
  title={Frequent Somatic Mutation in Adult Intestinal Stem Cells Drives Neoplasia and Genetic Mosaicism during Aging},
  author={Katarzyna Siudeja and Sonya Nassari and Louis Gervais and Patricia Skorski and Sonia Lameiras and Donato Stolfa and Maria Zande and Virginie Bernard and Thomas Rio Frio and Allison J Bardin},
  booktitle={Cell stem cell},
  year={2015}
}
Adult stem cells may acquire mutations that modify cellular behavior, leading to functional declines in homeostasis or providing a competitive advantage resulting in premalignancy. However, the frequency, phenotypic impact, and mechanisms underlying spontaneous mutagenesis during aging are unclear. Here, we report two mechanisms of genome instability in adult Drosophila intestinal stem cells (ISCs) that cause phenotypic alterations in the aging intestine. First, we found frequent loss of… CONTINUE READING
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