Frequent PTEN/MMAC mutations in endometrioid but not serous or mucinous epithelial ovarian tumors.

@article{Obata1998FrequentPM,
  title={Frequent PTEN/MMAC mutations in endometrioid but not serous or mucinous epithelial ovarian tumors.},
  author={Koshiro Obata and Sarah J. Morland and Richard H Watson and Andrew Hitchcock and Georgia Chenevix-Trench and Eric J. Thomas and Ian G. Campbell},
  journal={Cancer research},
  year={1998},
  volume={58 10},
  pages={2095-7}
}
Epithelial ovarian cancer comprises three major histological subtypes (serous, mucinous, and endometrioid), and it is becoming clear that the developmental pathways for these subtypes are fundamentally different. In particular, endometrioid ovarian cancers probably arise by the malignant transformation of ectopic endometrial implants called endometriosis and not the ovarian surface epithelium. The PTEN/MMAC gene on chromosome 10q23 is a tumor suppressor implicated in the pathogenesis of a wide… CONTINUE READING
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