Frequent MYC coamplification and DNA hypomethylation of multiple genes on 8q in 8p11-p12-amplified breast carcinomas

@inproceedings{Parris2014FrequentMC,
  title={Frequent MYC coamplification and DNA hypomethylation of multiple genes on 8q in 8p11-p12-amplified breast carcinomas},
  author={Toshima Z. Parris and Agota Kov{\'a}cs and Shahin Hajizadeh and Szil{\'a}rd Nemes and Maroun Semaan and Maxim Levin and Peter Karlsson and Khalil Helou},
  booktitle={Oncogenesis},
  year={2014}
}
Genetic and epigenetic (DNA methylation, histone modifications, microRNA expression) crosstalk promotes inactivation of tumor suppressor genes or activation of oncogenes by gene loss/hypermethylation or duplications/hypomethylation, respectively. The 8p11-p12 chromosomal region is a hotspot for genomic aberrations (chromosomal rearrangements, amplifications and deletions) in several cancer forms, including breast carcinoma where amplification has been associated with increased proliferation… CONTINUE READING
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