Frequent Intracellular Clonal Expansions of Somatic mtDNA Mutations

  title={Frequent Intracellular Clonal Expansions of Somatic mtDNA Mutations},
  author={Hilary A. Coller and Natalya D. Bodyak and Konstantin Khrapko},
  journal={Annals of the New York Academy of Sciences},
It has been proposed that age‐dependent accumulation of somatic mutations in mtDNA is responsible for some aspects of the aging process. However, most cells contain hundreds to thousands of mtDNA molecules. Any nascent somatic mutant therefore appears as a single copy among a majority of wild‐type species. A single mutant molecule is unlikely to influence the physiology of the cell and thus cannot play a role in the aging process. To affect cellular physiology, the nascent somatic mutants must… 

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