Frequent HLA class I and DP sequence mismatches in serologically (HLA-A, HLA-B, HLA-DR) and molecularly (HLA-DRB1, HLA-DQA1, HLA-DQB1) HLA-identical unrelated bone marrow transplant pairs.

@article{Santamaria1994FrequentHC,
  title={Frequent HLA class I and DP sequence mismatches in serologically (HLA-A, HLA-B, HLA-DR) and molecularly (HLA-DRB1, HLA-DQA1, HLA-DQB1) HLA-identical unrelated bone marrow transplant pairs.},
  author={Pere Santamaria and Nancy L. Reinsmoen and Alan L. Lindstrom and Michael T. Boyce-Jacino and Jose J. Barbosa and Anthony J. Faras and Philip B Mcglave and Stephen S. Rich},
  journal={Blood},
  year={1994},
  volume={83 1},
  pages={280-7}
}
The rates of graft-versus-host disease (GVHD) and rejection are significantly higher among recipients of unrelated donor marrow (BM) than in recipients of marrow from HLA-identical siblings, even when donors and recipients are mixed lymphocyte culture (MLC) compatible and serologically and Dw identical. It has been hypothesized that phenotypically silent HLA class I and DP sequence mismatches might be associated with these differences, but little is known about their incidence. We have… CONTINUE READING

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