Frequent Alterations of p 16 INK 4 a and p 14 ARF in Oral Proliferative Verrucous Leukoplakia

@inproceedings{Kresty2008FrequentAO,
  title={Frequent Alterations of p 16 INK 4 a and p 14 ARF in Oral Proliferative Verrucous Leukoplakia},
  author={Laura A. Kresty and Susan R. Mallery and Thomas J Knobloch and Junan Li and Mary Elizabeth Riley Lloyd and Bruce Cordell Casto and Christopher Weghorst},
  year={2008}
}
Proliferative verrucous leukoplakia (PVL) represents a rare but highly aggressive form of oral leukoplakia with >70% progressing to malignancy. Yet, PVL remains biologically and genetically poorly understood. This study evaluated the cell cycle regulatory genes, p16 and p14 , for homozygous deletion, loss of heterozygosity, and mutation events in 20 PVL cases. Deletion of exon 1B, 1A, or 2 was detected in 40%, 35%, and 0% of patients, respectively. Deletions of exons 1A and 1B markedly exceed… CONTINUE READING

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