Frequency-tuned distribution of inhibition in the dentate gyrus.

  title={Frequency-tuned distribution of inhibition in the dentate gyrus.},
  author={Laura A. Ewell and Mathew V. Jones},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={30 38},
Granule cells (GCs) of the dentate gyrus use sparse encoding to perform redundancy reduction, pattern separation, and novelty detection. One likely candidate mechanism to enforce low spiking activity is feedforward inhibition, in which the cortical excitatory drive from the perforant path (PP) recruits GABAergic interneurons that then inhibit GCs. Little is known, however, about how PP drive is balanced between GCs versus inhibitory neurons. In simultaneous recordings of GCs and fast-spiking… CONTINUE READING


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