Frequency of trisomy 15 and loss of the Y chromosome in adult leukemia.

@article{Smith1999FrequencyOT,
  title={Frequency of trisomy 15 and loss of the Y chromosome in adult leukemia.},
  author={A. Smith and N. Watson and P. Sharma},
  journal={Cancer genetics and cytogenetics},
  year={1999},
  volume={114 2},
  pages={
          108-11
        }
}
  • A. Smith, N. Watson, P. Sharma
  • Published 1999
  • Biology, Medicine
  • Cancer genetics and cytogenetics
  • In the interpretation of the varied and complex cytogenetic counts obtained in analysis of bone marrow (BM) samples for leukemia, loss or gain of certain chromosomes may or may not be significant for prognosis. Loss of the Y chromosome in elderly males is a benign finding. Trisomy 15 is rare and may represent another age-related abnormality, particularly in males, together with -Y. We reviewed 3,242 routine referrals sent to our laboratory for BM cytogenetics, over a period of 34 months. We… CONTINUE READING
    18 Citations
    [Incidence and clinical significance of sex chromosome losses in bone marrow of patients with hematologic diseases].
    • 6
    • Highly Influenced
    • PDF
    Isolated +15 in bone marrow: disease-associated or a benign finding?
    • 8
    Deletion 15q as the sole abnormality in acute myeloid leukemia: report of three cases and review of the literature.
    • 4
    Deletion of chromosome arm 15q and hitherto unreported duplication of del(15q) in myeloid disorders.
    • 4
    How I investigate Clonal cytogenetic abnormalities of undetermined significance
    • 8
    Three patients with 46,X,inv(Y)(p11.2q11.2)pat/45,X and their pedigree analysis

    References

    SHOWING 1-10 OF 13 REFERENCES
    Loss of the Y chromosome in acute myelogenous leukemia: a report of 13 patients.
    • 55
    The frequency of aneuploidy in cultured lymphocytes is correlated with age and gender but not with reproductive history.
    • 126
    A case of chronic myelomonocytic leukemia with isochromosome 14q.
    • 9
    Aneuploidy in culture.
    • 10
    International scoring system for evaluating prognosis in myelodysplastic syndromes.
    • 3,873
    • PDF
    Chromosome aneuploidy in Alzheimer's disease
    • 15
    Fluorodeoxyuridine synchronization of bone marrow cultures.
    • 204
    How does interferon exert its cell growth inhibitory effect?
    • 77