Frequency of the polymorphonuclear neutrophil Fc gamma receptor III deficiency in the French population and its involvement in the development of neonatal alloimmune neutropenia.

@article{Fromont1992FrequencyOT,
  title={Frequency of the polymorphonuclear neutrophil Fc gamma receptor III deficiency in the French population and its involvement in the development of neonatal alloimmune neutropenia.},
  author={Patricia Fromont and Ali Bettaieb and Hadef Skouri and Corinne Floch and E Poulet and N Du{\'e}dari and Philippe Bierling},
  journal={Blood},
  year={1992},
  volume={79 8},
  pages={2131-4}
}
We report the case of a healthy woman (K.M.) who, after multiple pregnancies, developed an antibody directed against a nonpolymorphic region of the polymorphonuclear neutrophil (PMN) Fc gamma receptor III (FcRIII-CD16), which caused transient neonatal alloimmune neutropenia (NAIN). The antigenic target of the antibody was determined by an immunoprecipitation procedure and by phenotyping the mother's PMN. These latter did not react with monoclonal CD16 or polyclonal and monoclonal NA1 and NA2… CONTINUE READING

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