Frequency of occurrence of idiotypes associated with anti-p- azophenylarsonate antibodies arising in mice immunologically suppressed with respect to a cross-reactive idiotype

@article{Ju1977FrequencyOO,
  title={Frequency of occurrence of idiotypes associated with anti-p- azophenylarsonate antibodies arising in mice immunologically suppressed with respect to a cross-reactive idiotype},
  author={S-T. Ju and A. Chas. E. Gray and Alfred Nisonoff},
  journal={The Journal of Experimental Medicine},
  year={1977},
  volume={145},
  pages={540 - 556}
}
Inoculation of rabbit anti-idiotypic (anti-id) antibodies suppresses the subsequent appearance of a cross-reactive idiotype (CRI) associated with the anti-p-azophenylarsonate (anti-Ar) antibodies of A/J mice. Such suppressed mice produce normal concentrations of anti-Ar antibodies which lack the CRI, but against which anti-id antisera can be prepared. The anti-Ar antibodies of an individual, suppressed mouse do not in general share idiotype with anti-Ar antibodies of other A/J mice, either… CONTINUE READING

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Evidence for somatic generation of antibody diversity.

Proceedings of the National Academy of Sciences of the United States of America • 1974

Genetic control of immune responsiveness

A. Nisonoff
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