Frequency of natural regulatory CD4+CD25+ T lymphocytes determines the outcome of tolerance across fully mismatched MHC barrier through linked recognition of self and allogeneic stimuli.

@article{Fucs2006FrequencyON,
  title={Frequency of natural regulatory CD4+CD25+ T lymphocytes determines the outcome of tolerance across fully mismatched MHC barrier through linked recognition of self and allogeneic stimuli.},
  author={Rita Fucs and Joszilene T. Jesus and Paulo H N Souza Junior and Larissa Franco and Maur{\'i}cio Afonso Ver{\'i}cimo and Maria Bellio and Alberto N{\'o}brega},
  journal={Journal of immunology},
  year={2006},
  volume={176 4},
  pages={2324-9}
}
We show in this study that long-term tolerance to allogeneic skin grafts can be established in the absence of immunosuppression by the combination of the following elements: 1) augmenting the frequency of regulatory CD4(+)CD25(+) T cells (Treg) and 2) presentation of the allogeneic stimuli through linked recognition of allo- and self-epitopes on… CONTINUE READING