Frequency of mtDNA A1555G and A7445G mutations among children with prelingual deafness in Turkey

@article{Tekin2002FrequencyOM,
  title={Frequency of mtDNA A1555G and A7445G mutations among children with prelingual deafness in Turkey},
  author={M. E. Tekin and T{\"u}rker Duman and G{\"o}n{\"u}l Boğoçlu and Armağan Incesulu and Elif Çomak and Suat Fitoz and Erkan Yılmaz and Inci Erg{\"u}rhan Ilhan and Nejat Akar},
  journal={European Journal of Pediatrics},
  year={2002},
  volume={162},
  pages={154-158}
}
Considerable differences on the frequencies of the mitochondrial 12S rRNA A1555G and tRNASer(UCN) A7445G mutations have been reported in different populations. Our screening of 168 patients coming from independent Turkish families with prelingual sensorineural non-syndromic deafness revealed three deaf children with A1555G (1.8%) but no examples of A7445G. One proband with the mitochondrial A1555G mutation has also evidence for right parietal infarct on a brain imaging study, for which common… CONTINUE READING