Frequency of fibroblast growth factor receptor 3 mutations in sporadic tumours

@article{Sibley2001FrequencyOF,
  title={Frequency of fibroblast growth factor receptor 3 mutations in sporadic tumours},
  author={Kathryn D Sibley and Peter Stern and Margaret A Knowles},
  journal={Oncogene},
  year={2001},
  volume={20},
  pages={4416-4418}
}
Mutations in FGFR3 have been identified in several tumour types including bladder carcinoma, cervical carcinoma, and multiple myeloma. In bladder carcinoma, we recently identified FGFR3 mutations in 41% of tumours, making this the most frequently mutated putative oncogene identified in bladder cancer to date. We have now investigated the frequency of FGFR3 mutation in a panel of 125 tumours and 13 cell lines from various other organs. We analysed the mutation hotspots in exons 7, 10 and 15 by… CONTINUE READING