Frequency of elevated biomarkers in patients with cryptogenic hepatocellular carcinoma

Abstract

BACKGROUND The incidence of hepatocellular carcinoma (HCC) continues to increase in Japan, but the clinical characteristics of Japanese patients with HCC have not been well described. The aim of this study was to determine the frequencies and utilities of elevated a-fetoprotein (AFP) and des-gamma-carboxy prothrombin (DCP) levels as biomarkers in cryptogenic HCC. MATERIAL/METHODS A total of 2638 patients with HCC diagnosed between 1999 and 2010 in the Nagasaki Association Study of Liver (NASLD) were recruited for this study. The cause of HCC was categorized into 4 groups; HCC-B, HCC-C, HCC-BC, and HCC-nonBC. The significance of factors was examined for HCC-nonBC using logistic regression analysis in all patients. RESULTS Multivariate analysis identified age, sex, BMI, alcohol consumption, platelet count, AST, ALT, AFP, DCP, and TNM stage as independent and significant risk factors for HCC-nonBC. According to TNM stage, the median AFP levels in HCC-nonBC with TNM stages I, II, and III were significantly lower than in either HCC-B or HCC-C. In TNM stage IV, the median AFP level in HCC-nonBC was significantly lower than in either HCC-B or HCC-BC. The median DCP levels in HCC-nonBC with TNM stages I and II were significantly higher than those in either HCC-B or HCC-C. In TNM stage III, the median DCP level in HCC-nonBC was significantly higher than that in HCC-C. CONCLUSIONS DCP was more sensitive than AFP for the diagnosis of early stage cryptogenic HCC. DCP should be used as the main serum test for cryptogenic HCC detection.

DOI: 10.12659/MSM.889361

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@inproceedings{Taura2013FrequencyOE, title={Frequency of elevated biomarkers in patients with cryptogenic hepatocellular carcinoma}, author={Naota Taura and Tatsuki Ichikawa and Hisamitsu Miyaaki and Eisuke Ozawa and Takuya Tsutsumi and Shotaro Tsuruta and Yuji Kato and Takashi Goto and Noboru Kinoshita and Masanori Fukushima and Hiroyuki Kato and Kazuyuki Ohata and Kazuo Ohba and Junichi Masuda and Keisuke Hamasaki and Hiroshi Yatsuhashi and Kazuhiko Nakao}, booktitle={Medical science monitor : international medical journal of experimental and clinical research}, year={2013} }