Frequency of anti‐nuclear antibodies in multiple sclerosis

@article{Barned1995FrequencyOA,
  title={Frequency of anti‐nuclear antibodies in multiple sclerosis},
  author={S. Barned and A. Goodman and D. Mattson},
  journal={Neurology},
  year={1995},
  volume={45},
  pages={384 - 385}
}
Article abstract—We found anti-nuclear antibodies (ANA) in 26.7% of 150 relapsing-remitting and in 30.4% of 23 chronic progressive definite multiple sclerosis (MS) patients bv retromective chart review. These Datients did not have systemic hpus emhemato&. Since ANA are not pathogenically relevant in MS, they are false-positive, and likely reflect systemic immune dys-regulation in MS. 
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References

SHOWING 1-9 OF 9 REFERENCES
Autoantibodies versus clinical symptoms in blood donors.
TLDR
A group of 255 blood donors was analyzed for the presence of serum autoantibodies, e.g., antinuclear antibodies, smooth muscle antibodies, antimitochondrial antibodies, antiparietal cell antibodies and antireticulin antibodies and found no strong evidence of disease in any of the blood donors with autoantibia. Expand
McAlpine's multiple sclerosis
SECTION 1 EPIDEMIOLOGY the Epidemiology of Multiple Sclerosis SECTION 2 CLINICAL ASPECTS Symptoms and Signs. Symptoms and Signs Contd. Some Aspects of the Natural History. Course and Prognosis.Expand
MS: a CNS and systemic autoimmune disease.
TLDR
The evidence is discussed that there are T-cell abnormalities in MS similar to those observed in other autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis, and that the immunoregulatory defects in the blood of MS patients appear to be accompanied by the rapid migration of activated T cells from the peripheral blood to the CNS. Expand
Isoelectric focusing of IgG eluted from multiple sclerosis and subacute sclerosing panencephalitis brains
TLDR
Isoelectric focusing (IEF) is used to compare IgG eluted from control brain, three plaques and a white matter pool of an MS brain, and three regions of an SSPE brain to suggest a common response to the same antigen. Expand
The clinical aspects.
  • J. Spillane
  • Medicine
  • Proceedings of the Royal Society of Medicine
  • 1962
TLDR
Pulmonary delivery of aerosol pharmaceutical agents is of increasing interest in medicine for a variety of reasons, and it is important in the field of Biomedical Imaging to visualize these various drugs in 3-D. Expand
Multiple sclerosis and related conditions, chapter 33
  • Joynt R, ed. Clinical neurology. Philadelphia: JB Lippincott,
  • 1993
Detection, isolation, and characterization
  • J Immunol