Frequency of anti‐nuclear antibodies in multiple sclerosis

  title={Frequency of anti‐nuclear antibodies in multiple sclerosis},
  author={Sydney Barned and Andrew D Goodman and David H. Mattson},
  pages={384 - 385}
Article abstract—We found anti-nuclear antibodies (ANA) in 26.7% of 150 relapsing-remitting and in 30.4% of 23 chronic progressive definite multiple sclerosis (MS) patients bv retromective chart review. These Datients did not have systemic hpus emhemato&. Since ANA are not pathogenically relevant in MS, they are false-positive, and likely reflect systemic immune dys-regulation in MS. 
Frequency and significance of antinuclear antibodies in multiple sclerosis
In a prospective sample of patients with multiple sclerosis, a high frequency of antinuclear antibodies (ANA) was found, 22.5%, confirming results from previous studies and suggesting that the high frequency in MS reflects ongoing immune dysregulation. Expand
A young Asian woman is described who had clinical and serological features of both diseases and whose mother has scleroderma, suggesting MS, SLE and other auto-immune disorders may run in the same family. Expand
Do elevated autoantibodies in patients with multiple sclerosis matter?
The aim of the study was to reassess the value of elevated serum autoantibodies in a study cohort of patients with multiple sclerosis. Expand
Multiple sclerosis, neuropsychiatric lupus and antiphospholipid syndrome: where do we stand?
When assessing MS patients, clinicians should consider APS/SLE, especially if the MS has atypical features, and it is essential to differentiate them since APS may be responsive to anticoagulation. Expand
Isolated anti‐β2‐glycoprotein I antibodies in neurology: a frontier syndrome between multiple sclerosis and antiphospholipid syndrome?
The objective was to analyse the clinical, radiological and therapeutic characteristics of neurological patients with positive anti‐β2‐GPI antibodies and without the Sapporo criteria for APS. Expand
Elevated Concentrations of Soluble Fas and FasL in Multiple Sclerosis Patients with Antinuclear Antibodies
There is a potential link between the presence of ANA and peripheral lymphocyte apoptosis mediated by Fas/FasL system in MS, whose precise role and significance needs to be determined by future mechanistic studies. Expand
Can Neurologic Manifestations of Hughes (Antiphospholipid) Syndrome Be Distinguished from Multiple Sclerosis?: Analysis of 27 Patients and Review of the Literature
A careful medical history, a previous history of thrombosis and/or fetal loss, an abnormal localization of the lesions in MRI, and the response to anticoagulant therapy might be helpful in the differential diagnosis. Expand
Frequency and significance of anti‐Ro (SS‐A) antibodies in multiple sclerosis patients
ANA, ACA and anti‐Ro (SS‐A) antibodies in MS patients indicate an underlying autoimmune disease but the series suggests that they are an epiphenomenon of a more diffuse immunological dysfunction. Expand
Autoimmunity in multiple sclerosis: study of a wide spectrum of autoantibodies
A generalised immune dysregulation occurs in MS patients, mostly during the acute stages and in the progressive courses, involving activation of both autoreactive Th1-cells (mainly linked to CNS lesions) and B-cells via Th2 cells. Expand
Should we systematically test patients with clinically isolated syndrome for auto-antibodies?
Antinuclear-antibodies, anti-SSA and anti-SSB should not be routinely determined in CIS patients but only in those presenting symptoms suggestive of other ADs. Expand


Autoantibodies versus clinical symptoms in blood donors.
A group of 255 blood donors was analyzed for the presence of serum autoantibodies, e.g., antinuclear antibodies, smooth muscle antibodies, antimitochondrial antibodies, antiparietal cell antibodies and antireticulin antibodies and found no strong evidence of disease in any of the blood donors with autoantibia. Expand
McAlpine's multiple sclerosis
SECTION 1 EPIDEMIOLOGY the Epidemiology of Multiple Sclerosis SECTION 2 CLINICAL ASPECTS Symptoms and Signs. Symptoms and Signs Contd. Some Aspects of the Natural History. Course and Prognosis.Expand
MS: a CNS and systemic autoimmune disease.
The evidence is discussed that there are T-cell abnormalities in MS similar to those observed in other autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis, and that the immunoregulatory defects in the blood of MS patients appear to be accompanied by the rapid migration of activated T cells from the peripheral blood to the CNS. Expand
Isoelectric focusing of IgG eluted from multiple sclerosis and subacute sclerosing panencephalitis brains
Isoelectric focusing (IEF) is used to compare IgG eluted from control brain, three plaques and a white matter pool of an MS brain, and three regions of an SSPE brain to suggest a common response to the same antigen. Expand
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Pulmonary delivery of aerosol pharmaceutical agents is of increasing interest in medicine for a variety of reasons, and it is important in the field of Biomedical Imaging to visualize these various drugs in 3-D. Expand
Multiple sclerosis and related conditions, chapter 33
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