Frequency of XY sperm increases with age in fathers of boys with Klinefelter syndrome.

  title={Frequency of XY sperm increases with age in fathers of boys with Klinefelter syndrome.},
  author={Xiu R Lowe and Brenda Eskenazi and David O. Nelson and Sharon A Kidd and Aaron M Alme and Andrew J. Wyrobek},
  journal={American journal of human genetics},
  volume={69 5},
With increasing availability of drugs for impotence and advanced reproductive technologies for the treatment of subfertility, more men are fathering children at advanced ages. We conducted a study of the chromosomal content of sperm of healthy men aged 24-57 years to (a) determine whether father's age was associated with increasing frequencies of aneuploid sperm including XY, disomy X, disomy Y, disomy 21, and sperm diploidy, and (b) examine the association between the frequencies of disomy 21… CONTINUE READING
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