Frequency of TP 53 codon 72 polymorphism in cases with colon cancer

@inproceedings{Onrat2009FrequencyOT,
  title={Frequency of TP 53 codon 72 polymorphism in cases with colon cancer},
  author={Serap Tutgun Onrat and Ender Ellidokuz and Ali K{\"u}pelioğlu and Emine Durhan},
  year={2009}
}
Recent studies indicated that the Arg allele is preferentially mutated and retained in various human cancers arising in Pro/Arg heterozygotes and it may be an important biomarker in colon cancer prognosis. In this study, DNA was isolated from paraffine-embedded colon tumor tissue samples of 35 cases diagnosed as colon carcinoma. We have observed PCR-RFLP genotyping for the codon 72 exon 4 polymorphism (Arg72Pro) of the p53 gene. In this study, we detected that TP53 codon 72 polymorphism was… CONTINUE READING
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