Frequency of TERT promoter mutations in primary tumors of the liver

@article{Quaas2014FrequencyOT,
  title={Frequency of TERT promoter mutations in primary tumors of the liver},
  author={Alexander M Quaas and Theresa Oldopp and Lars Tharun and Catina Klingenfeld and Till Krech and Guido Sauter and Tobias J. Grob},
  journal={Virchows Archiv},
  year={2014},
  volume={465},
  pages={673-677}
}
Transcriptional regulation of the TERT gene is a major cause of the cancer-specific increase in telomerase activity. Recently, frequent somatic mutations in the TERT promoter have been described in several tumor entities such as melanoma, glioblastoma, bladder cancer, and hepatocellular carcinoma. By generating a putative consensus binding site for ETS… CONTINUE READING