Frequency of RAS gene mutation and its cooperative genetic events in Southeast Asian adult acute myeloid leukemia.

@article{Auewarakul2006FrequencyOR,
  title={Frequency of RAS gene mutation and its cooperative genetic events in Southeast Asian adult acute myeloid leukemia.},
  author={Chirayu Udomsakdi Auewarakul and Darat Lauhakirti and Chintana Tocharoentanaphol},
  journal={European journal of haematology},
  year={2006},
  volume={77 1},
  pages={51-6}
}
RAS gene as one of the most frequently mutated genes in acute myeloid leukemia (AML) has become an attractive target for molecular therapy. The role of oncogenic RAS and its associated genetic events in AML are not yet defined. We examined the frequency of RAS mutation in 239 Thai de novo adult AML patients using polymerase chain reaction-single-strand conformational polymorphism analysis. Thirty-five RAS mutations were found in 32 cases (13%) predominantly classified as M1/M2 (53%) followed by… CONTINUE READING