Frequency of Mycobacterium tuberculosis-specific CD8+ T-cells in the course of anti-tuberculosis treatment.

@article{AxelssonRobertson2015FrequencyOM,
  title={Frequency of Mycobacterium tuberculosis-specific CD8+ T-cells in the course of anti-tuberculosis treatment.},
  author={R. Axelsson-Robertson and M. Rao and A. Loxton and G. Walzl and M. Bates and Alimuddin Zumla and M. Maeurer},
  journal={International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases},
  year={2015},
  volume={32},
  pages={
          23-9
        }
}
  • R. Axelsson-Robertson, M. Rao, +4 authors M. Maeurer
  • Published 2015
  • Biology, Medicine
  • International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
Anti-tuberculosis drug treatment is known to affect the number, phenotype, and effector functionality of antigen-specific T-cells. In order to objectively gauge Mycobacterium tuberculosis (MTB)-specific CD8+ T-cells at the single-cell level, we developed soluble major histocompatibility complex (MHC) class I multimers/peptide multimers, which allow analysis of antigen-specific T-cells without ex vivo manipulation or functional tests. We constructed 38 MHC class I multimers covering some of the… Expand
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