Frequency of MRP1 genetic polymorphisms and their functional significance in Caucasians: detection of a novel mutation G816A in the human MRP1 gene

@article{Oselin2003FrequencyOM,
  title={Frequency of MRP1 genetic polymorphisms and their functional significance in Caucasians: detection of a novel mutation G816A in the human MRP1 gene},
  author={Kersti Oselin and Przemysław Michał Mrozikiewicz and Elena A. Gaikovitch and Rein P{\"a}hkla and Ivar Roots},
  journal={European Journal of Clinical Pharmacology},
  year={2003},
  volume={59},
  pages={347-350}
}
The aim of the present study was to determine the frequency of the G816A, T825C, T1684C, and G4002A genetic polymorphisms of the human MRP1 gene in 230 healthy Caucasians. The functional assessment of these mutations was performed in fluorescence-activated cell sorting (FACS)-sorted peripheral blood CD4+ cells in a further 61 healthy volunteers by determining MRP1 mRNA expression. Genotyping of the MRP1 was carried out using real-time polymerase chain reaction (PCR) assays. Quantitative… CONTINUE READING

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Identification of human multidrug resistance protein 1 ( MRP 1 ) mutations and characterization of a G 671 V substitution

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