Frequency of MED12 mutations in phyllodes tumors: Inverse correlation with histologic grade.

@article{Yoon2016FrequencyOM,
  title={Frequency of MED12 mutations in phyllodes tumors: Inverse correlation with histologic grade.},
  author={Nara Yoon and Go Eun Bae and So Young Kang and Mi Sun Choi and Hye Won Hwang and Seok Won Kim and Jeong Eon Lee and Seok Jin Nam and Gyungyub Gong and Hee Jin Lee and Young Kyung Bae and Ahwon Lee and Eun Yoon Cho},
  journal={Genes, chromosomes & cancer},
  year={2016},
  volume={55 6},
  pages={
          495-504
        }
}
Phyllodes tumor (PT) is a rare breast biphasic tumor with a potential risk of recurrence and metastasis. In this study, the frequency of MED12 mutations in 176 PTs (49 benign, 49 borderline, and 78 malignant) was determined and the prognostic effect of these mutations in malignant type PT was evaluated. Analysis of MED12 mutations was performed by Sanger sequencing targeting the hotspot mutation region (exon 2) of MED12. Immunohistochemistry was also applied for evaluation of MED12 protein… CONTINUE READING
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