Frequency of K-ras mutations in pancreatic intraductal neoplasias associated with pancreatic ductal adenocarcinoma and chronic pancreatitis: a meta-analysis.

@article{Lhr2005FrequencyOK,
  title={Frequency of K-ras mutations in pancreatic intraductal neoplasias associated with pancreatic ductal adenocarcinoma and chronic pancreatitis: a meta-analysis.},
  author={Matthias L{\"o}hr and Guenter Kloeppel and Patrick Maisonneuve and Albert B. Lowenfels and Jutta Luettges},
  journal={Neoplasia},
  year={2005},
  volume={7 1},
  pages={17-23}
}
Molecular analyses have demonstrated mutations in the K-ras gene at codon 12 in the majority of pancreatic ductal adenocarcinomas (PDACs). In order to determine whether the K-ras mutation rate increases parallel to the grade of dysplasia in duct lesions, we performed a meta-analysis of the studies published between 1988 and 2003 that provide information on K-ras mutations in hyperplastic and dysplastic duct lesions in the pancreas. The described duct lesions were reclassified according to the… CONTINUE READING