Frequency of C3435T single nucleotide MDR1 genetic polymorphism in an Asian population: phenotypic-genotypic correlates.

@article{Balram2003FrequencyOC,
  title={Frequency of C3435T single nucleotide MDR1 genetic polymorphism in an Asian population: phenotypic-genotypic correlates.},
  author={Chowbay Balram and Anita Sharma and Cumaraswamy Sivathasan and Edmund Jon Deoon Lee},
  journal={British journal of clinical pharmacology},
  year={2003},
  volume={56 1},
  pages={78-83}
}
AIMS To investigate the frequency of the single nucleotide polymorphism C3435T in exon 26 of the MDR1 gene in Asians and to determine the functional significance of this SNP with the clinical pharmacokinetics of oral cyclosporin (Neoral) in 10 stable heart transplant patients. METHODS The MDR1 C3435T polymorphism was investigated in 290 healthy Asian subjects (98 Chinese, 99 Malays and 93 Indians). We also compared the MDR1 polymorphism between the Asian population studied here and the… CONTINUE READING