Frequency of BRCA1 mutation 5382insC in German breast cancer patients.

  title={Frequency of BRCA1 mutation 5382insC in German breast cancer patients.},
  author={J Backe and Sigrun Hofferbert and Britta Skawran and Thilo D{\"o}rk and Manfred Stuhrmann and Johann Hinrich Karstens and Michael Untch and Alfons Meindl and Renate Burgemeister and Jenny Chang-Claude and Bernhard H F Weber},
  journal={Gynecologic oncology},
  volume={72 3},
OBJECTIVE The aim of the study was to determine the frequency of the BRCA1 mutation 5382insC in German breast cancer patients with and without prior knowledge of a family history of breast cancer. METHODS Two groups of breast cancer patients were tested for the presence or absence of the 5382insC mutation using a PCR primer mismatch assay. A sample of 248 patients unrelated by genealogy was selected based on a history of breast and/or ovarian cancer in the families. In addition, a population… CONTINUE READING
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