Frequency of BRCA1 dysfunction in ovarian cancer.

  title={Frequency of BRCA1 dysfunction in ovarian cancer.},
  author={John P Geisler and Melanie A Hatterman-Zogg and Jennifer A. Rathe and Richard E. Buller},
  journal={Journal of the National Cancer Institute},
  volume={94 1},
BACKGROUND Ovarian cancer is one of the most common hereditary cancers in women. Mutations in the BRCA1 gene increase a woman's risk of ovarian cancer. Testing for BRCA1 mutations is cumbersome and impractical for large populations. Therefore, we developed an efficient strategy to detect various types of BRCA1 dysfunction and also determined the relative frequency of BRCA1 dysfunction in ovarian cancer. METHODS Tumors from 221 patients with epithelial ovarian cancer were screened for loss of… CONTINUE READING


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Publications referenced by this paper.
Showing 1-10 of 28 references

BRCA1 promoter region hypermethylation in ovarian cancer: a population-based study

RL Baldwin, E Nemeth, +3 authors BY. Karlan
Cancer Res • 2000

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